Ingredients / Licorice
Licorice
EMERGINGHerb6 min readLicorice is primarily used for its anti-inflammatory and gastrointestinal benefits, though human evidence is mixed and often limited by study quality.
Clinical Dose
150-300 mg per day
Best Form
Look for: Look for a standardized Licorice form with transparent potency labeling.
How it works
Licorice contains glycyrrhizin, which inhibits 11β-hydroxysteroid dehydrogenase, leading to increased cortisol levels that can reduce inflammation. It also has demulcent properties that soothe mucous membranes, potentially aiding in gastrointestinal relief.
Who should take it
Individuals with mild gastrointestinal discomfort or those seeking anti-inflammatory benefits.
Who should avoid it
Pregnant women, individuals with hypertension, or those on corticosteroids should avoid due to potential exacerbation of these conditions.
Side effects
Potential side effects include hypertension, hypokalemia, and edema, particularly with high doses or prolonged use.
Common forms
Standardized Licorice form
What the research says
Human studies on licorice show potential benefits for peptic ulcers and functional dyspepsia, with doses around 150-300 mg of glycyrrhizin. However, results are inconsistent, and many studies lack rigorous design. More high-quality trials are needed to confirm efficacy and safety.
Efficacy of Licorice in Functional Dyspepsia
Licorice extract improved symptoms in 50% of participants compared to 30% in placebo group.
View study
Food sources
Licorice root is the natural source, commonly used in herbal teas and traditional remedies.
In depth: Licorice
Licorice, a flowering plant native to Europe and Asia, has been used for centuries in traditional medicine, particularly in India, for its purported health benefits. It is primarily known for its active compound glycyrrhizin, which is responsible for many of its therapeutic properties. In India, licorice is commonly used in Ayurvedic remedies to treat respiratory issues, digestive problems, and inflammatory conditions. Unlike dietary sources like licorice candy, which often contain artificial flavors and high sugar content, supplements provide concentrated forms of the herb's bioactive compounds. Scientific research on licorice is emerging, with some studies highlighting its potential anti-inflammatory, gastroprotective, and antiviral properties. However, the evidence is mixed, and many studies are limited by small sample sizes and methodological issues. While promising, more rigorous clinical trials are needed to solidify its evidence base, particularly in Indian populations.
Key benefits
- ✓Anti-inflammatory effects: Glycyrrhizin may reduce inflammation by inhibiting inflammatory pathways, though evidence is moderate.
- ✓Gastrointestinal relief: Licorice can soothe the stomach lining and may aid in managing peptic ulcers and functional dyspepsia (Emerging evidence).
- ✓Antiviral properties: Some studies suggest it may help combat certain viral infections, including hepatitis C (Limited evidence).
- ✓Respiratory support: Traditionally used to alleviate coughs and asthma symptoms, with some supporting research (Moderate evidence).
- ✓Skin health: Topical application may help with eczema and other inflammatory skin conditions (Limited evidence).
How to take it
The optimal dose of licorice for most adults ranges from 150 to 300 mg of glycyrrhizin per day, typically divided into two doses. It is best taken with food to minimize the risk of gastrointestinal discomfort. While there is no strict cycling requirement, long-term use should be avoided due to potential side effects like hypertension. Stacking licorice with other supplements like ginger or turmeric may enhance its anti-inflammatory effects, but consult a healthcare provider for personalized advice. In India, licorice supplements are commonly available in capsule form, with typical doses ranging from 200 to 500 mg per capsule. Prices vary, but quality products usually cost between ₹500 to ₹1500 for a month's supply.
Forms compared
DGL (Deglycyrrhizinated Licorice)
Contains less glycyrrhizin, reducing the risk of side effects like hypertension. Suitable for long-term use but may be less effective for certain conditions.
Standardized Extract
Contains a standardized amount of glycyrrhizin, ensuring consistent potency. Ideal for those seeking the full benefits but requires careful monitoring for side effects.
Whole Root Powder
Offers a full spectrum of compounds but lacks standardization. May be less potent and harder to dose accurately.
Safety & interactions
Licorice is generally safe when used short-term and within recommended doses. However, it can cause side effects like hypertension, hypokalemia, and edema, especially with prolonged use or in high doses. Individuals with hypertension, heart disease, or kidney issues should avoid licorice or use it under medical supervision. It may interact with medications like diuretics, blood pressure medications, and corticosteroids, potentially exacerbating side effects. In India, where metformin and statins are commonly prescribed, caution is advised as licorice could interfere with these drugs' metabolism. Pregnant and breastfeeding women should avoid licorice due to potential risks to fetal development and infant health. Long-term use is not recommended without medical guidance.
India context
Licorice has a long history of use in traditional Indian medicine, particularly in Ayurveda, where it is valued for its anti-inflammatory and digestive properties. Despite its widespread use, there is no specific data on licorice deficiency in India, but its demand remains high due to its role in traditional remedies. The regulatory status of licorice in India is governed by the FSSAI, which ensures quality and safety standards. However, the market is prone to adulteration, with red flags including products containing added sugars or artificial additives. Quality licorice supplements typically cost between ₹500 to ₹1500 for a month's supply. It is most beneficial for individuals with inflammatory conditions, digestive issues, or those seeking respiratory support, particularly those with Pitta-dominant body types.
Buying guide
When purchasing licorice supplements, look for products that clearly state the amount of glycyrrhizin per serving. Prefer supplements with third-party certifications like FSSAI, NSF, or Informed Sport to ensure quality and purity. Avoid products with proprietary blends or those that do not disclose the concentration of active compounds. Additionally, be wary of supplements containing artificial colors, flavors, or unnecessary fillers. Reading the ingredient list is crucial; opt for products with minimal ingredients and clear labeling. In India, standardized extracts are preferable due to their consistent potency, but DGL forms can be considered for those concerned about side effects. Always consult a healthcare provider before starting licorice supplementation, especially if you have pre-existing health conditions or are taking medications.
Bottom line
Licorice can be a valuable supplement for those seeking anti-inflammatory and digestive support, particularly if they have conditions like peptic ulcers or functional dyspepsia. However, it is not suitable for everyone and should be used with caution, especially in high doses or long-term. For most, a standardized extract at 150-300 mg of glycyrrhizin per day is recommended. Always consult a healthcare provider before use, particularly if you have health concerns or are on medications.
Frequently asked questions
Does licorice cause any side effects?▾
Yes, licorice can cause side effects like hypertension, hypokalemia, and edema, especially with prolonged use or in high doses.
When is the best time to take licorice?▾
Licorice is best taken with food to minimize the risk of gastrointestinal discomfort. Divided doses throughout the day are recommended.
Is licorice safe for vegetarians?▾
Most licorice supplements are vegetarian-friendly, but always check the label to confirm.
Can licorice interact with medications?▾
Yes, licorice may interact with medications like diuretics, blood pressure medications, and corticosteroids. Consult a healthcare provider for personalized advice.
Is licorice safe for pregnant women?▾
Pregnant and breastfeeding women should avoid licorice due to potential risks to fetal development and infant health.
Products with Licorice
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